|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein.
|
23707765 |
2013 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
When used alone or in combination with LXY-LS-DOX, M-RAPA could greatly inhibit the expression of HIF-1α protein, which is always highly expressed in malignant cancers and involved in tumor angiogenesis, proliferation, therapeutic resistance and poor prognosis.
|
24726747 |
2014 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We put a special focus on the transcription factor HIF-1α, a master regulator of tumor angiogenesis.The interaction of CDK5 with HIF-1α was tested by Western blot, PCR, reporter gene assay, immunohistochemistry, kinase assay, co-immunoprecipitation, mass spectrometry, and mutation studies.
|
27027353 |
2016 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We provide a possible mechanism in which peritoneal dissemination of gastric cancer develops via a vascular network whereby HIF-1α activates tumor angiogenesis.
|
23970191 |
2013 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We propose that the mechanism underlying the inhibitory effects of bortezomib on tumor angiogenesis and hypoxic adaptation involves the repression of HIF-1alpha transcriptional activity by reinforcing the FIH-mediated inhibition of p300 recruitment.
|
18174379 |
2008 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We examined the effect of nelfinavir, an HIV protease inhibitor that inhibits Akt signaling, on VEGF and HIF-1alpha expression and on angiogenesis, tumor oxygenation, and radiosensitization.
|
16982770 |
2006 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Vascular endothelial growth factor A (VEGFA), a critical mediator of tumor angiogenesis, is a well-characterized target of hypoxia-inducible factor 1 (HIF-1).
|
20194889 |
2010 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Vascular endothelial growth factor (VEGF), a crucial factor in tumor angiogenesis, has been reported to be transcriptionally regulated by hypoxia-inducible factor-1 (HIF-1).
|
30906512 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Using ovarian and endometrial cancer cell lines, we observed that TM downregulates HIF-1α protein levels and HIF-transcriptional targets involved in tumor angiogenesis and glycolysis, but did not affect HIF-1α protein synthesis.
|
26469226 |
2015 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Under hypoxic conditions, mARD1(225) autoacetylation inhibited tumor angiogenesis by decreasing the stability of hypoxia-inducible factor-1α (HIF-1α).
|
25338643 |
2015 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes tumor angiogenesis via upregulating the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF).
|
30103950 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To the best of our knowledge, results of the present study provide the first evidence that miR-181b was upregulated by hypoxia in retinoblastoma in an HIF-1α-independent manner. miR-181b increased tumor angiogenesis of retinoblastoma cells.
|
25872572 |
2015 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
To investigate the implication of the hypoxia inducible factor HIF-1alpha mRNA in gastric carcinoma and its relation to the expression of vascular endothelial growth factor (VEGF) protein, tumor angiogenesis invasion/metastasis and the patient's survival.
|
17461470 |
2007 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, LSD1 is a key regulator of HIF1α/VEGF-mediated tumor angiogenesis by antagonizing the crosstalk between PTMs involving HIF1α protein degradation.
|
28534506 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study aimed at determining the expression levels of HIF-1alpha and vascular endothelial growth factor (VEGF) in SW480 cells and in colorectal adenocarcinoma tissue and ascertaining whether HIF-1alpha and VEGF play important roles in tumor angiogenesis.
|
15498380 |
2004 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results showed that TSA had a potent anticancer activity on TSCC cells, suggesting that TSA could be a promising drug targeting tumor angiogenesis via inhibition of HIF-1α and VEGF expression in the development of an effective chemopreventive and anticancer agent on human TSCCs.
|
22552321 |
2012 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results indicated that in prostate cancers, HIF-1 might cooperate with the AR to activate the expression of several genes related to tumor angiogenesis, invasion, and progression.
|
17426252 |
2007 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate that BH4 domain of bcl-2 is required for the ability of this protein to increase tumor angiogenesis and progression and indicate that bcl-2 nuclear localization may be required for bcl-2-mediated induction of HIF-1/VEGF axis.
|
23836782 |
2013 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These findings reveal a novel role of apigenin in inhibiting HIF-1 and VEGF expression that is important for tumor angiogenesis and growth, identifying new signaling molecules that mediate this regulation.
|
15746177 |
2005 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These data provide a molecular basis for VEGF induction and tumor angiogenesis by heregulin-HER2 signaling and establish a novel mechanism for the regulation of HIF-1alpha expression.
|
11359907 |
2001 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These data indicate that activation of c-Kit by SCF leads to a predominantly HIF-1alpha-mediated enhancement of VEGF expression and that inhibition of c-Kit signaling with imatinib could result in inhibition of tumor angiogenesis.
|
16818499 |
2006 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therefore, heparanase and HIF-1α facilitated tumor angiogenesis and promoted pulmonary metastasis of osteosarcoma.
|
20845995 |
2010 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
There is strong scientific rationale for combination therapy: transarterial chemoembolization produces ischemia and stimulates hypoxia-inducible factor-1α, resulting in a local and systemic upregulation of vascular endothelial growth factor (VEGF), which can increase tumor angiogenesis.
|
23562168 |
2013 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumor angiogenesis, growth, and metastasis and is recognized as an important potential therapeutic target for cancer.
|
30728113 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The results suggest that Trx-1 increases HIF-1alpha protein levels in cancer cells and increases VEGF production and tumor angiogenesis.
|
12208766 |
2002 |